CAS No. 28047-15-6
| CAS Number | 28047-15-6 | |
|---|---|---|
| Molecular Formula |
C13H16N2O4 |
|
| Molecular Weight (MW) | 264.28 | |
| SMILES | C1=CC=C(C=C1)CC(=O)NC(CCC(=O)N)C(=O)O |
Phenylacetylglutamine is a gut microbiota-derived phenylalanine metabolite that acts via G-protein coupled receptors, including alpha2A, alpha2B, and beta2 adrenergic receptors. Activation of these adrenergic receptors triggers downstream signaling pathways that elevate intracellular calcium levels and foster platelet hyperresponsiveness. This heightened signaling promotes enhanced thrombosis potential and accelerates clot formation, linking gut microbial metabolism directly to cardiovascular disease phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
52 mg/mL
(196.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
53 mg/mL
(200.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 53 mg/mL |
| Ethanol | 53 mg/mL |
| DMSO |
52 mg/mL
(196.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 52 mg/mL |
| Ethanol | 52 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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