CAS No. 73-05-2
Batch:
Purity:98.69
Chemical Structure
Check the
phentolamine hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 73-05-2 | |
|---|---|---|
| Molecular Formula |
C17H19N3O.ClH |
|
| Molecular Weight (MW) | 317.81 |
Phentolamine hydrochloride is a potent, non-selective antagonist of α1- and α2-adrenergic receptors. By blocking α-adrenergic signaling pathways, it prevents catecholamine-mediated vasoconstriction, promoting smooth muscle relaxation and vasodilation. This inhibition suppresses sympathetic nervous system tone and modulates vascular resistance, rendering it a valuable tool for investigating adrenergic receptor function in cardiovascular and neural pathways. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
| DMSO |
56 mg/mL
(176.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.