CAS No. 81267-65-4

Batch: Purity:99.99
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Phenoxodiol (Haginin E) Chemical Structure
Chemical Structure
Check the Phenoxodiol (Haginin E) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(4-hydroxyphenyl)-2H-chromen-7-ol
CAS Number 81267-65-4
Molecular Formula

C15H12O3
Molecular Weight (MW) 240.25
SMILES C1C(=CC2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O
InChIKey ZZUBHVMHNVYXRR-UHFFFAOYSA-N

Biological Activity

Phenoxodiol is a synthetic isoflavone analog with antineoplastic activity that targets topoisomerase II and disrupts anti-apoptotic pathways. It inhibits X-linked inhibitor of apoptosis (XIAP) and downregulates FLICE inhibitory protein (FLIP) expression, leading to the activation of the caspase cascade. These molecular events restore apoptotic signaling and induce programmed cell death in chemoresistant tumor cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 48 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kamsteeg M, et al. Oncogene. 2003;22(17):2611-20.

[2] Oncogene. 2006;25(11):1593-1593.

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Note: Technical data last updated: Sep 1, 2026.