CAS No. 92-43-3
Batch:
Purity:98
Chemical Structure
Check the
Phenidone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-phenylpyrazolidin-3-one | |
|---|---|---|
| CAS Number | 92-43-3 | |
| Molecular Formula |
C9H10N2O |
|
| Molecular Weight (MW) | 162.19 | |
| SMILES | C1CN(NC1=O)C2=CC=CC=C2 | |
| InChIKey | CMCWWLVWPDLCRM-UHFFFAOYSA-N |
Phenidone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes. By suppressing both the COX and LOX signaling pathways, it blocks the enzymatic conversion of arachidonic acid into eicosanoids, including prostaglandins and leukotrienes. This dual pathway inhibition downstream attenuates inflammatory mediator biosynthesis, reduces cellular lipid peroxidation, and suppresses pro-inflammatory responses in biological models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(197.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.