CAS No. 2009343-14-8
Batch:
Purity:99.81
Chemical Structure
Check the
PHD-1-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile | |
|---|---|---|
| CAS Number | 2009343-14-8 | |
| Molecular Formula |
C13H8N4 |
|
| Molecular Weight (MW) | 220.23 | |
| SMILES | N#CC1=CC=C(C=C1)C2=CC=CC3=NC=N[N]23 | |
| InChIKey | DEYMFBHALUHGST-UHFFFAOYSA-N |
PHD-1-IN-1 is a potent and orally active inhibitor targeting hypoxia-inducible factor prolyl hydroxylase domain-1 (PHD-1) [1]. It binds to the active site Fe2+ ion through a monodentate interaction, suppressing PHD-1-mediated proline hydroxylation [1]. Inhibition of PHD-1 prevents oxygen-dependent degradation of hypoxia-inducible factors, thereby regulating downstream HIF signaling pathways involved in cellular hypoxic responses and gene transcription. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(22.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.