CAS No. 1462249-75-7
| IUPAC Name | (E)-1-pyridin-4-yl-3-[7-(trifluoromethyl)quinolin-2-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 1462249-75-7 | |
| Molecular Formula |
C18H11F3N2O |
|
| Molecular Weight (MW) | 328.29 | |
| SMILES | C1=CC(=CC2=C1C=CC(=N2)C=CC(=O)C3=CC=NC=C3)C(F)(F)F | |
| InChIKey | IAJOMYABKVAZCN-AATRIKPKSA-N |
PFK158 is a potent and selective inhibitor targeting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). By blocking PFKFB3 enzymatic activity, the compound suppresses glycolytic flux, decreases intracellular fructose-2,6-bisphosphate levels, and impairs glucose utilization in cancer cells. Downstream inhibition of this glycolytic pathway restricts energetic signaling, inhibits cell proliferation, and induces apoptotic cell death, resulting in significant tumor growth inhibition across preclinical cancer models. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(42.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
15 mg/mL
(45.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(201.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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