CAS No. 947303-87-9

Batch: Purity:98.99
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PF 429242 Chemical Structure
Chemical Structure
Check the PF 429242 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide
CAS Number 947303-87-9
Molecular Formula

C25H35N3O2
Molecular Weight (MW) 409.56
SMILES CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)C3CCNC3
InChIKey XKPJTOHUPQWSOJ-HSZRJFAPSA-N

Ordering Information

Biological Activity

PF 429242 is a selective site-1 protease (S1P) inhibitor (IC50 = 170 nM) that displays high selectivity over other serine proteases. By inhibiting S1P, PF 429242 blocks the endoproteolytic cleavage and activation of sterol regulatory element-binding proteins (SREBPs). This disruption of the SREBP signaling pathway suppresses downstream lipogenic target gene expression, ultimately leading to reduced cellular cholesterol and fatty acid synthesis.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 82 mg/mL
Ethanol 82 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.