CAS No. 2070014-93-4
Batch:
Purity:99.99
Chemical Structure
Check the
PF-CBP1 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine;hydrochloride | |
|---|---|---|
| CAS Number | 2070014-93-4 | |
| Molecular Formula |
C29H36N4O3.HCl |
|
| Molecular Weight (MW) | 525.08 | |
| SMILES | CCCOC1=CC=C(C=C1)CCC2=NC3=C(N2CCN4CCOCC4)C=CC(=C3)C5=C(ON=C5C)C.Cl | |
| InChIKey | HFOZCHHWLMTUTP-UHFFFAOYSA-N |
PF-CBP1 HCl is a highly selective inhibitor targeting CREBBP and p300 bromodomains. By targeting these acetyl-lysine reader domains, it disrupts chromatin coactivator complex assembly and regulates downstream transcriptional pathways. This selective inhibition impairs CREBBP- and p300-mediated gene expression programs, resulting in suppressed cell proliferation and altered downstream transcriptional phenotypes across target cellular models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(190.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.