CAS No. 2569009-58-9
Batch:
Purity:99.87
Chemical Structure
Check the
PF-9363 (CTx-648)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2,6-dimethoxy-N-[4-methoxy-6-(pyrazol-1-ylmethyl)-1,2-benzoxazol-3-yl]benzenesulfonamide | |
|---|---|---|
| CAS Number | 2569009-58-9 | |
| Molecular Formula |
C20H20N4O6S |
|
| Molecular Weight (MW) | 444.46 | |
| SMILES | COC1=CC(=CC2=C1C(=NO2)N[S](=O)(=O)C3=C(OC)C=CC=C3OC)C[N]4C=CC=N4 | |
| InChIKey | VNSQFPFWUAZOTQ-UHFFFAOYSA-N |
Biological Activity
PF-9363 (CTx-648) is a potent and selective KAT6A and KAT6B histone acetyltransferase inhibitor. It inhibits histone H3K23 acetylation and reduces RNA Polymerase II binding, leading to the downregulation of genes involved in estrogen signaling, cell cycle, Myc, and stem cell pathways. Consequently, PF-9363 exhibits robust anti-tumor activity and inhibits tumor growth in estrogen receptor-positive breast cancer models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
89 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
89 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.