CAS No. 950912-80-8

Batch: Purity:99.98
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PF-670462 Chemical Structure
Chemical Structure
Check the PF-670462 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride
CAS Number 950912-80-8
Molecular Formula

C19H22Cl2FN5
Molecular Weight (MW) 410.32
SMILES C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl
InChIKey PSNKGVAXBSAHCH-UHFFFAOYSA-N

Ordering Information

Biological Activity

PF-670462 is a potent and selective inhibitor of casein kinase 1 delta (CK1δ) and casein kinase 1 epsilon (CK1ε). By inhibiting CK1δ and CK1ε activity, it disrupts the phosphorylation of core clock proteins within the circadian timing system, downstream modulating circadian signaling pathways and lengthening the circadian period in biological models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 82 mg/mL
Ethanol 25 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.