CAS No. 1811510-56-1
Batch:
Purity:99.79
Chemical Structure
Check the
PF-6260933
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(6-amino-3-pyridinyl)-3-(4-chlorophenyl)pyridin-2-amine | |
|---|---|---|
| CAS Number | 1811510-56-1 | |
| Molecular Formula |
C16H13ClN4 |
|
| Molecular Weight (MW) | 296.75 | |
| SMILES | C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl | |
| InChIKey | KHPCIHZXOGHCLY-UHFFFAOYSA-N |
PF-6260933 is a potent inhibitor of MAP4K4 with high kinome selectivity. By selectively targeting MAP4K4 kinase activity, this compound suppresses downstream signaling cascades through the JNK pathway. Consequently, MAP4K4 inhibition regulates key cellular and vascular phenotypes, inhibiting cell migration, protecting endothelial function, and attenuating pro-inflammatory gene expression in cell-based models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(198.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.