CAS No. 1390637-82-7
Batch:
Purity:99.93
Chemical Structure
Check the
PF-4981517
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-methyl-3-[1-methyl-5-(4-methylphenyl)pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]pyrazolo[5,4-d]pyrimidine | |
|---|---|---|
| CAS Number | 1390637-82-7 | |
| Molecular Formula |
C26H32N8
|
|
| Molecular Weight (MW) | 456.59 | |
| SMILES | CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CCC(C5)N6CCCCC6)C | |
| InChIKey | WDWIMDKOXZZYHH-FQEVSTJZSA-N |
PF-4981517 (CYP3cide) is a potent cytochrome P450 inhibitor targeting CYP3A4 with an IC50 of, exhibiting >500-fold selectivity over CYP3A5 and CYP3A7. By selectively inactivating CYP3A4, it blocks CYP3A4-mediated substrate oxidation and drug metabolism pathways. This selective inhibition enables the functional differentiation of CYP3A4 from CYP3A5 contributions in human liver microsomal metabolic studies. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.