CAS No. 3033846-10-2
Chemical Structure
Check the
PF-07899895
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[3-[(1-aminocyclohexyl)methoxy]-4-cyano-5-methylsulfanylphenyl]imidazo[1,2-a]pyridine-5-carbonitrile | |
|---|---|---|
| CAS Number | 3033846-10-2 | |
| Molecular Formula |
C23H23N5OS |
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| Molecular Weight (MW) | 417.53 | |
| InChIKey | LTQKUGJNXFIXKC-UHFFFAOYSA-N |
PF-07899895 is a potent inhibitor of salt-inducible kinase (SIK) isoforms, including SIK1, SIK2, and SIK3. By inhibiting SIK activity, it blocks the phosphorylation of downstream substrates such as CRTC family proteins, promoting CRTC nuclear translocation and driving the production of the anti-inflammatory cytokine IL-10 in immune cells. This pathway modulation regulates macrophage phenotype and suppresses pro-inflammatory signaling, highlighting its utility in inflammatory disease research.
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Note: Technical data last updated: Sep 1, 2026.