CAS No. 2736458-30-1
Batch:
Purity:99.41
Chemical Structure
Check the
PF-07265028
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(1R)-1-aminopropyl]-2-[6-[(5S)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl]-2-pyridinyl]-6-[(2R)-2-methylpyrrolidin-1-yl]-3H-pyrrolo[3,4-c]pyridin-1-one | |
|---|---|---|
| CAS Number | 2736458-30-1 | |
| Molecular Formula |
C26H32N8O |
|
| Molecular Weight (MW) | 472.59 | |
| InChIKey | FOLSZCLZVLICGG-JTDSTZFVSA-N |
PF-07265028 is a potent and selective small-molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1/MAP4K1). Inhibition of HPK1 activity suppresses HPK1-dependent phosphorylation of SLP76 within the T cell receptor (TCR) signaling complex. Downstream, attenuating this negative regulatory mechanism restores intracellular signaling, promoting enhanced T cell activation, increased cytokine production, and augmented immune effector responses. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 42 mg/mL |
| DMSO |
30 mg/mL
(63.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.