CAS No. 2569008-99-5
Chemical Structure
Check the
PF-07248144(Prifetrastat)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-methoxy-N-[4-methoxy-6-(pyrazol-1-ylmethyl)-1,2-benzoxazol-3-yl]benzenesulfonamide | |
|---|---|---|
| CAS Number | 2569008-99-5 | |
| Molecular Formula |
C19H18N4O5S |
|
| Molecular Weight (MW) | 414.44 | |
| InChIKey | RCBWSTJGOASLEO-UHFFFAOYSA-N |
Biological Activity
PF-07248144 (Prifetrastat) is a potent and selective catalytic inhibitor of histone acetyltransferases KAT6A and KAT6B. By suppressing KAT6A and KAT6B activity, the compound inhibits targeted histone acetylation and disrupts chromatin-mediated gene transcription. Downstream, this catalytic blockade triggers cell cycle arrest and cellular senescence, thereby inhibiting tumor cell proliferation and conferring durable antitumor activity in metastatic breast cancer models. [1]
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Note: Technical data last updated: Sep 1, 2026.