CAS No. 1801333-55-0
Batch:
Purity:98.29
Chemical Structure
Check the
PF-06952229
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[[2-(5-chloro-2-fluorophenyl)-5-propan-2-yl-4-pyridinyl]amino]-N-(1,3-dihydroxypropan-2-yl)pyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 1801333-55-0 | |
| Molecular Formula |
C23H24ClFN4O3 |
|
| Molecular Weight (MW) | 458.91 | |
| InChIKey | IPBLCOKXDQHSQW-UHFFFAOYSA-N |
Biological Activity
PF-06952229 is a selective, orally bioavailable small-molecule inhibitor of TGF-β receptor 1 (TGF-β-R1/ALK5). By blocking TGF-β-R1 kinase activity, it suppresses SMAD2 phosphorylation in both tumor and immune cells, thereby interrupting canonical TGF-β signaling and reversing epithelial-mesenchymal transition in vitro. Consequently, PF-06952229 modulates the tumor immune microenvironment and demonstrates robust antitumor activity in preclinical mouse models.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.