CAS No. 2127109-84-4

Batch: Purity:99.48
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Ropsacitinib (PF-06826647) Chemical Structure
Chemical Structure
Check the Ropsacitinib (PF-06826647) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(cyanomethyl)-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]cyclobutane-1-carbonitrile
CAS Number 2127109-84-4
Molecular Formula

C20H17N9
Molecular Weight (MW) 383.41
SMILES CN1C=C(C=N1)C2=CN3C(=CC=N3)C(=N2)C4=CN(N=C4)C5(CC(C5)C#N)CC#N
InChIKey XPLZTJWZDBFWDE-UHFFFAOYSA-N

Ordering Information

Biological Activity

Ropsacitinib (PF-06826647) is an orally active, selective tyrosine kinase 2 inhibitor that targets the TYK2 catalytic JH1 domain, as well as JAK1 and JAK2. By suppressing TYK2-dependent kinase activity, it disrupts downstream JAK-STAT signaling pathways activated by pro-inflammatory cytokines such as IL-12 and IL-23. Consequently, ropsacitinib attenuates inflammatory gene expression and immune cell activation, demonstrating potent anti-inflammatory efficacy in psoriasis models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (200.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.