CAS No. 1792180-81-4
Batch:
Purity:99.99
Chemical Structure
Check the
PF-06651600 (Ritlecitinib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 1792180-81-4 | |
| Molecular Formula |
C15H19N5O |
|
| Molecular Weight (MW) | 285.34 | |
| SMILES | CC1CCC(CN1C(=O)C=C)NC2=NC=NC3=C2C=CN3 | |
| InChIKey | CBRJPFGIXUFMTM-WDEREUQCSA-N |
PF-06651600 (Ritlecitinib) is a potent, irreversible inhibitor of JAK3 (IC50 = with no activity against JAK1, JAK2, or TYK2 (IC50 > 10,000 nM). By selectively target-inhibiting JAK3, it blocks signaling downstream of common gamma chain cytokine receptors, suppressing STAT phosphorylation and downstream T cell and natural killer cell activation and function. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 46 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- PF-06651600 (Ritlecitinib) Clinical Trials
- PF-06651600 (Ritlecitinib) Solubility in DMSO
- PF-06651600 (Ritlecitinib) Stock Solution
- PF-06651600 (Ritlecitinib) Storage
- PF-06651600 (Ritlecitinib) Stability
- PF-06651600 (Ritlecitinib) Molecular Weight
- PF-06651600 (Ritlecitinib) SMILES
- PF-06651600 (Ritlecitinib) Chemical Structure (2D and 3D)
- PF-06651600 (Ritlecitinib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.