CAS No. 1527473-33-1
Batch:
Purity:99.97
Chemical Structure
Check the
PF-06447475
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile | |
|---|---|---|
| CAS Number | 1527473-33-1 | |
| Molecular Formula |
C17H15N5O |
|
| Molecular Weight (MW) | 305.33 | |
| SMILES | C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N | |
| InChIKey | BHTWDJBVZQBRKP-UHFFFAOYSA-N |
PF-06447475 is a potent, selective, and brain-penetrant leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 of 3 nM. By suppressing LRRK2 kinase activity, it attenuates cellular LRRK2 autophosphorylation and downregulates downstream signaling cascades implicated in neurodegeneration. In preclinical models, PF-06447475 exhibits high central nervous system permeability and mitigates LRRK2-driven cellular phenotypes, serving as a valuable tool in Parkinson's disease research.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
61 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.