CAS No. 1632250-49-7
Batch:
Purity:99.71
Chemical Structure
Check the
PF-06446846
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(3-chloro-2-pyridinyl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide | |
|---|---|---|
| CAS Number | 1632250-49-7 | |
| Molecular Formula |
C22H20ClN7O |
|
| Molecular Weight (MW) | 433.89 | |
| SMILES | C1CC(CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4 | |
| InChIKey | FDTXHWQFIXYHCL-QGZVFWFLSA-N |
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) translation inhibitor. It selectively inhibits PCSK9 synthesis by stalling the 80S ribosome near the early coding region of PCSK9 mRNA. By arresting translation on the ribosome, PF-06446846 reduces secreted PCSK9 levels, increasing low-density lipoprotein receptor expression on liver cells and promoting low-density lipoprotein cholesterol clearance. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(200.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
87 mg/mL
(200.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.