CAS No. 1469284-79-4
| IUPAC Name | [(3R)-1-[2-[1-(4-chloropyrazol-1-yl)cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanone;methanesulfonic acid | |
|---|---|---|
| CAS Number | 1469284-79-4 | |
| Molecular Formula |
C23H30ClN7O4S |
|
| Molecular Weight (MW) | 536.05 | |
| SMILES | C[S](O)(=O)=O.ClC1=C[N](N=C1)C2(CC2)C3=NC4=CC=C(N=C4[NH]3)N5CCCC(C5)C(=O)N6CCCC6 | |
| InChIKey | ZSTFDNQQOJUJFL-XFULWGLBSA-N |
PF-06424439 Methanesulfonate is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT2) with an IC50 of 14 nM. By inhibiting DGAT2, it disrupts the final step of triacylglycerol synthesis, blocking the esterification of diacylglycerol with fatty acyl-CoA. This targeted inhibition reduces intracellular triglyceride accumulation, decreases hepatic lipid droplet formation, and suppresses triglyceride secretion in metabolic disease models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(164.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 88 mg/mL |
| Ethanol | 88 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- PF-06424439 Methanesulfonate Solubility in DMSO
- PF-06424439 Methanesulfonate Stock Solution
- PF-06424439 Methanesulfonate Storage
- PF-06424439 Methanesulfonate Stability
- PF-06424439 Methanesulfonate Molecular Weight
- PF-06424439 Methanesulfonate SMILES
- PF-06424439 Methanesulfonate Chemical Structure (2D and 3D)
- PF-06424439 Methanesulfonate SDS｜MSDS