CAS No. 1467057-23-3
Batch:
Purity:99.44
Chemical Structure
Check the
PF-06409577
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid | |
|---|---|---|
| CAS Number | 1467057-23-3 | |
| Molecular Formula |
C19H16ClNO3 |
|
| Molecular Weight (MW) | 341.79 | |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O | |
| InChIKey | FHQXLWCFSUSXBF-UHFFFAOYSA-N |
PF-06409577 is an orally bioavailable allosteric activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 offor the α1β1γ1 isoform. Activation of AMPK by PF-06409577 promotes downstream phosphorylation of acetyl-CoA carboxylase, thereby regulating lipid metabolism and cellular energy homeostasis. Additionally, this compound shows no significant inhibition of hERG potassium channels or major human cytochrome P450 enzymes.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(292.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.