CAS No. 1370448-25-1
Batch:
Purity:99.58
Chemical Structure
Check the
PF-05221304
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1370448-25-1 | |
|---|---|---|
| Molecular Formula |
C28H30N4O5 |
|
| Molecular Weight (MW) | 502.56 | |
| SMILES | COC1=CC(=CC(=N1)C2=CC=C(C=C2)C(O)=O)C(=O)N3CCC4(CC3)CC(=O)C5=C(C4)C=N[N]5C(C)C |
PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), which plays a key role in lipid metabolism. By inhibiting ACC, the compound suppresses the initial committed step of hepatic de novo lipogenesis (DNL), thereby decreasing fatty acid synthesis and suppressing hepatic lipid accumulation. This targeted modulation of lipogenic activity attenuates triglyceride accumulation and cellular steatosis in liver tissue. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.