CAS No. 1622902-68-4

Batch: Purity:99.45
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Abrocitinib (PF-04965842) Chemical Structure
Chemical Structure
Check the Abrocitinib (PF-04965842) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
CAS Number 1622902-68-4
Molecular Formula

C14H21N5O2S
Molecular Weight (MW) 323.41
SMILES CCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3
InChIKey IUEWXNHSKRWHDY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Abrocitinib (PF-04965842) is an orally active Janus kinase inhibitor that potently targets JAK1 with selectivity over JAK2, TYK2, and JAK3 (IC50 >. By selectively blocking JAK1 activity, it suppresses cytokine-stimulated JAK-STAT signaling pathways, preventing STAT protein phosphorylation and downregulating downstream pro-inflammatory gene expression to attenuate immune-mediated inflammatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (200.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.