CAS No. 1078166-57-0
Batch:
Purity:99.99
Chemical Structure
Check the
PF-04418948
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid | |
|---|---|---|
| CAS Number | 1078166-57-0 | |
| Molecular Formula |
C23H20FNO5 |
|
| Molecular Weight (MW) | 409.41 | |
| SMILES | COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O | |
| InChIKey | LWJGMYMNSNVCEM-UHFFFAOYSA-N |
PF-04418948 is a potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM. By selectively binding to the EP2 receptor, it inhibits PGE2-stimulated cyclic AMP (cAMP) accumulation and downstream signal transduction. This targeted inhibition effectively attenuates EP2-mediated inflammatory responses and vascular tone regulation, suppressing downstream pro-inflammatory gene expression and signaling cascades in cell-based assays.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(197.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
82 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.