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Pexidartinib is an ATP-competitive CSF-1R inhibitor. It blocks PI3K/AKT signaling by preventing ATP entry, halting tumor growth.
Pexidartinib (PLX3397) Mechanism of Action: CSF1R Inhibition in Synovial Macrophage Research
Pexidartinib (PLX3397) MOA：Targeting CSF1R/CSF1 Signaling Pathway for Tenosynovial Giant Cell Tumor (TGCT) Therapeutics