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MLN4924 (Pevonedistat) is a potent NEDD8-activating enzyme (NAE) inhibitor. It affects PI3K/AKT, NF-κB, and RhoA/ROCK signaling pathways by blocking Cullin-RING ligase neddylation and stabilizing substrates like p21 and p27, thereby inhibiting cancer cell proliferation, migration, and inducing apoptosis.