CAS No. 58-39-9
| IUPAC Name | 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol | |
|---|---|---|
| CAS Number | 58-39-9 | |
| Molecular Formula |
C21H26ClN3OS |
|
| Molecular Weight (MW) | 403.97 | |
| SMILES | C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO | |
| InChIKey | RGCVKNLCSQQDEP-UHFFFAOYSA-N |
Perphenazine is a phenothiazine derivative that functions as a dopamine receptor antagonist with potent antipsychotic and antiemetic activities. It also acts as a small-molecule activator of protein phosphatase 2A (PP2A), promoting PP2A-mediated dephosphorylation of downstream targets. This activation suppresses oncogenic AKT/mTOR signaling pathways, leading to inhibited cell proliferation and the induction of apoptotic cell death in leukemia models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(183.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 74 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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