CAS No. 53910-25-1

Batch: Purity:99.98
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Pentostatin Chemical Structure
Chemical Structure
Check the Pentostatin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
CAS Number 53910-25-1
Molecular Formula

C11H16N4O4
Molecular Weight (MW) 268.27
SMILES C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
InChIKey FPVKHBSQESCIEP-JQCXWYLXSA-N

Ordering Information

Biological Activity

Pentostatin (CI-825, Deoxycoformycin) is a potent inhibitor of adenosine deaminase (ADA). Inhibition of ADA blocks purine metabolism, causing intracellular accumulation of deoxyadenosine nucleotides, including deoxyadenosine triphosphate (dATP). This metabolic imbalance impairs DNA synthesis and repair mechanisms, leading to selective cytotoxicity and apoptosis in lymphoproliferative malignancies as well as pronounced immunosuppressive effects in lymphocytes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 54 mg/mL (201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 54 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.