CAS No. 41372-02-5

Batch: Purity:
Penicillin G benzathine tetrahydrate Chemical Structure
Chemical Structure
Check the Penicillin G benzathine tetrahydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 41372-02-5
Molecular Formula

C16H20N2.2C16H18N2O4S.4H2O
Molecular Weight (MW) 981.19

Biological Activity

Penicillin G benzathine tetrahydrate is a long-acting beta-lactam antibiotic that targets bacterial penicillin-binding proteins. By binding to and inactivating penicillin-binding proteins, it inhibits transpeptidase-mediated peptidoglycan cross-linking during bacterial cell wall synthesis. This inhibition impairs cell wall integrity, leading to osmotic lysis and bacterial cell death. Consequently, it exhibits potent antibacterial activity against various susceptible bacterial infections, including impetigo.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.