CAS No. 944118-01-8

Batch: Purity:99.69
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Peficitinib (ASP015K) Chemical Structure
Chemical Structure
Check the Peficitinib (ASP015K) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
CAS Number 944118-01-8
Molecular Formula

C18H22N4O2
Molecular Weight (MW) 326.39
SMILES C1C2CC3CC(C2)(CC1C3NC4=C5C=CNC5=NC=C4C(=O)N)O
InChIKey DREIJXJRTLTGJC-JQCLMNFQSA-N

Ordering Information

Biological Activity

Peficitinib (ASP015K) is an orally bioavailable Janus kinase (JAK) inhibitor that targets JAK family enzymes, including JAK1, JAK2, JAK3, and TYK2. By inhibiting JAK activity, peficitinib blocks downstream STAT protein phosphorylation and suppresses canonical JAK/STAT signaling pathways. This inhibition reduces pro-inflammatory cytokine-mediated signaling and downstream gene expression, suppressing immune cell activation and tissue inflammation in preclinical models of autoimmune and inflammatory diseases.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.