CAS No. 520-12-7
Batch:
Purity:99.87
Chemical Structure
Check the
Pectolinarigenin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one | |
|---|---|---|
| CAS Number | 520-12-7 | |
| Molecular Formula |
C17H14O6 |
|
| Molecular Weight (MW) | 314.29 | |
| SMILES | COC1=CC=C(C=C1)C2=CC(=O)C3=C(O)C(=C(O)C=C3O2)OC | |
| InChIKey | GPQLHGCIAUEJQK-UHFFFAOYSA-N |
Pectolinarigenin is a natural flavonoid acting as a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). By simultaneously blocking COX-2 and 5-LOX enzymatic pathways, it attenuates the downstream biosynthesis of pro-inflammatory eicosanoids, including prostaglandin E2 and leukotrienes. This dual pathway inhibition suppresses pro-inflammatory signaling and dampens inflammatory cellular phenotypes in experimental disease models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(318.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.