CAS No. 1032508-03-4
Batch:
Purity:99.59
Chemical Structure
Check the
PDM-11
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1032508-03-4 | |
|---|---|---|
| Molecular Formula |
C16H15ClO2 |
|
| Molecular Weight (MW) | 274.74 | |
| SMILES | COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)Cl)OC |
PDM-11 is a synthetic resveratrol derivative that acts as a selective antagonist of the aryl hydrocarbon receptor (AhR), displaying higher binding affinity for AhR than resveratrol while showing no affinity for estrogen receptors. By blocking AhR activation, PDM-11 inhibits ligand-induced nuclear translocation and transcriptional activation of AhR target genes, such as CYP1A1. This targeted inhibition modulates downstream signaling pathways involved in xenobiotic metabolism and cellular proliferation. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(200.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.