CAS No. 212631-67-9
Batch:
Purity:99.53
Chemical Structure
Check the
PD184161
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-bromo-2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide | |
|---|---|---|
| CAS Number | 212631-67-9 | |
| Molecular Formula |
C17H13BrClF2IN2O2 |
|
| Molecular Weight (MW) | 557.56 | |
| SMILES | FC1=C(Br)C=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl | |
| InChIKey | VJNZMSLGVUSPCF-UHFFFAOYSA-N |
Biological Activity
PD184161 is an orally active MEK inhibitor targeting the RAF/MEK/ERK signaling cascade. By suppressing MEK activity, it blocks downstream phosphorylation of ERK1/2 within the MAPK pathway. This pathway inhibition leads to the suppression of cell proliferation and the induction of apoptosis in sensitive cell populations. Targeted inhibition of this cascade demonstrates the central role of MEK in regulating cellular survival and growth dynamics. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(179.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.