CAS No. 217171-01-2

Batch: Purity:99.89
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PD173212 Chemical Structure
Chemical Structure
Check the PD173212 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-N-[(2S)-1-(tert-butylamino)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-tert-butylphenyl)methyl-methylamino]-4-methylpentanamide
CAS Number 217171-01-2
Molecular Formula

C38H53N3O3
Molecular Weight (MW) 599.85
InChIKey GCDHMGROXQUFNR-HEVIKAOCSA-N

Biological Activity

PD173212 is a selective N-type voltage-sensitive calcium channel (VSCC) blocker with an IC50 of 36 nM in IMR-32 functional assays. By inhibiting N-type calcium channels, PD173212 suppresses cellular calcium influx and neuronal signaling pathways involved in neurotransmitter release. This targeted channel blockade disrupts calcium-dependent signal transduction, leading to neuroprotective and antinociceptive phenotypes in preclinical disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 120 mg/mL (200.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 120 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hu LY, et al. Bioorg Med Chem Lett. 1999;9(15):2151-6.

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Note: Technical data last updated: Sep 1, 2026.