CAS No. 153436-54-5
Batch:
Purity:99.33
Chemical Structure
Check the
PD153035
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine | |
|---|---|---|
| CAS Number | 153436-54-5 | |
| Molecular Formula |
C16H14BrN3O2 |
|
| Molecular Weight (MW) | 360.21 | |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC | |
| InChIKey | LSPANGZZENHZNJ-UHFFFAOYSA-N |
PD153035 is a highly potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (Ki =. By rapidly suppressing ligand-induced EGFR autophosphorylation, PD153035 blocks downstream activation of the MAPK/ERK and PI3K/AKT signaling pathways. Inhibition of these critical survival pathways impairs tumor cell growth and suppresses growth factor-stimulated proliferation in EGFR-dependent cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(16.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.