CAS No. 185039-89-8
Batch:
Purity:99.59
Chemical Structure
Check the
PD0166285
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 185039-89-8 | |
| Molecular Formula |
C26H27Cl2N5O2 |
|
| Molecular Weight (MW) | 512.43 | |
| SMILES | CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl | |
| InChIKey | IFPPYSWJNWHOLQ-UHFFFAOYSA-N |
PD0166285 is a potent inhibitor of Wee1 and Myt1 that also targets Chk1. By suppressing these G2 checkpoint kinases, PD0166285 acts as a G2 checkpoint abrogator to override DNA damage-induced cell cycle arrest. This disruption promotes premature mitotic entry, accumulation of DNA damage, and the induction of apoptosis. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.