CAS No. 1675201-83-8
Batch:
Purity:99.84
Chemical Structure
Check the
BMS-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid | |
|---|---|---|
| CAS Number | 1675201-83-8 | |
| Molecular Formula |
C29H33NO5 |
|
| Molecular Weight (MW) | 475.58 | |
| SMILES | CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC | |
| InChIKey | ZBOYJODMIAUJHH-SANMLTNESA-N |
BMS-1 is a small-molecule inhibitor of the PD-1/PD-L1 interaction. By binding directly to PD-L1, BMS-1 prevents the engagement between PD-1 and PD-L1, disrupting downstream immune checkpoint signaling pathways. Blockade of this interaction effectively reverses PD-L1-mediated T-cell immunosuppression and restores cytotoxic T-lymphocyte function, leading to enhanced immune response and cytokine production in cellular assays. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 95 mg/mL |
| Ethanol | 5 mg/mL |
| DMSO |
95 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 95 mg/mL |
| Ethanol | 95 mg/mL |
| Ethanol | 95 mg/mL |
| DMSO |
5.9 mg/mL
(12.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.