CAS No. 1215011-08-7

Batch: Purity:99.58
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Zelenirstat (PCLX-001) Chemical Structure
Chemical Structure
Check the Zelenirstat (PCLX-001) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,6-dichloro-N-[1,5-dimethyl-3-(2-methylpropyl)pyrazol-4-yl]-4-(2-piperazin-1-yl-4-pyridinyl)benzenesulfonamide
CAS Number 1215011-08-7
Molecular Formula

C24H30Cl2N6O2S
Molecular Weight (MW) 537.51
InChIKey WKTSLVQYGBHNRV-UHFFFAOYSA-N

Ordering Information

Biological Activity

Zelenirstat (PCLX-001) is an orally active dual N-myristoyltransferase (NMT) inhibitor targeting NMT1 and NMT2. Treatment with PCLX-001 impairs global protein N-myristoylation, suppressing early B-cell receptor (BCR) signaling pathways essential for cell survival and inducing apoptosis in lymphoma models. Furthermore, inhibition of NMT disrupts mitochondrial respiratory complex I assembly by downregulating NDUFAF4, leading to the loss of oxidative phosphorylation and cellular respiration. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (37.2 mM) ; Warmed with 60°C water bath ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.