CAS No. 950762-95-5
Batch:
Purity:99.79
Chemical Structure
Check the
PCI-34051
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide | |
|---|---|---|
| CAS Number | 950762-95-5 | |
| Molecular Formula |
C17H16N2O3 |
|
| Molecular Weight (MW) | 296.32 | |
| SMILES | COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO | |
| InChIKey | AJRGHIGYPXNABY-UHFFFAOYSA-N |
Biological Activity
PCI-34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor with an IC50 of. It exhibits over 200-fold selectivity for HDAC8 over HDAC1 and HDAC6, and more than 1000-fold selectivity over HDAC2, HDAC3, and HDAC10. PCI-34051 induces mitochondrial cytochrome c release and caspase-dependent apoptosis, demonstrating selective cytotoxic activity against T-cell malignancy cell lines without causing widespread histone or tubulin hyperacetylation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
59 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
59 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.