CAS No. 57186-25-1
Chemical Structure
Check the
Paxilline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one | |
|---|---|---|
| CAS Number | 57186-25-1 | |
| Molecular Formula |
C27H33NO4 |
|
| Molecular Weight (MW) | 435.56 | |
| InChIKey | ACNHBCIZLNNLRS-UBGQALKQSA-N |
Biological Activity
Paxilline is an indole alkaloid mycotoxin that acts as a potent inhibitor of large-conductance calcium-activated potassium (BK) channels and sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA) with IC50 values ranging from 5 μM to 50 μM. Direct inhibition of BK channels reduces membrane K+ efflux, modulating intracellular calcium dynamics and cellular excitability. Disruption of SERCA-mediated calcium transport alters lumenal Ca2+ homeostasis, producing downstream neuroprotective and anticonvulsant physiological phenotypes. [1]
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Note: Technical data last updated: Sep 1, 2026.