Parsaclisib (INCB050465) Hydrochloride

For research use only.

Catalog No.S8779 Synonyms: IBI376

Parsaclisib (INCB050465) Hydrochloride Chemical Structure

CAS No. 1995889-48-9

Parsaclisib (INCB050465, IBI376) Hydrochloride is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

Purity & Quality Control

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Biological Activity

Description Parsaclisib (INCB050465, IBI376) Hydrochloride is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
Targets
PI3Kδ [1]
(in biochemical assay)
1 nM

Protocol

Solubility (25°C)

In vitro DMSO 94 mg/mL (200.28 mM)
Water Insoluble
Ethanol ''94 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.34
Formula

C20H23Cl2FN6O2

CAS No. 1995889-48-9
Storage powder
in solvent
Synonyms IBI376
Smiles CCOC1=C(C(=C(C=C1C(C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)C4CC(=O)NC4

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04831996 Recruiting Drug: parsaclisib Advanced Malignancies Incyte Corporation May 4 2021 Phase 1
NCT04774068 Not yet recruiting Drug: Parsaclisib|Drug: Romidepsin Recurrent Anaplastic Large Cell Lymphoma|Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Recurrent Transformed Mycosis Fungoides|Refractory Anaplastic Large Cell Lymphoma|Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Refractory Transformed Mycosis Fungoides|T-Cell Non-Hodgkin Lymphoma Ohio State University Comprehensive Cancer Center May 1 2021 Phase 1
NCT04831944 Recruiting Drug: parsaclisib Advanced Malignancies Incyte Corporation March 29 2021 Phase 1
NCT04142554 Withdrawn Drug: Parsaclisib Breast Cancer|Breast Neoplasms|Triple Negative Breast Cancer|HER2-positive Breast Cancer UNC Lineberger Comprehensive Cancer Center|Incyte Corporation June 1 2020 Phase 1
NCT04298879 Recruiting Drug: IBI376 Indolent Non-hodgkin Lymphoma Innovent Biologics (Suzhou) Co. Ltd. April 7 2020 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PI3K Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID