CAS No. 61869-08-7
Batch:
Purity:99.06
Chemical Structure
Check the
Paroxetine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine | |
|---|---|---|
| CAS Number | 61869-08-7 | |
| Molecular Formula |
C19H20FNO3 |
|
| Molecular Weight (MW) | 329.37 | |
| InChIKey | AHOUBRCZNHFOSL-YOEHRIQHSA-N |
Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter. By blocking serotonin reuptake, it increases extracellular serotonin levels to modulate central neurotransmission. Additionally, paroxetine inhibits pyroptosis and suppresses osteoclast formation through inhibition of the NF-kB signaling pathway, thereby reducing inflammatory responses and bone resorption in experimental models. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.