CAS No. 1216941-48-8
Batch:
Purity:99.97
Chemical Structure
Check the
Paritaprevir (ABT-450)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1216941-48-8 | |
|---|---|---|
| Molecular Formula |
C40H43N7O7S |
|
| Molecular Weight (MW) | 765.88 | |
| SMILES | CC1=CN=C(C=N1)C(=O)NC2CCCCCC=CC3CC3(NC(=O)C4CC(CN4C2=O)OC5=NC6=CC=CC=C6C7=CC=CC=C75)C(=O)NS(=O)(=O)C8CC8 |
Paritaprevir (ABT-450) is a potent hepatitis C virus (HCV) NS3/4A protease inhibitor. It targets the active site of the viral NS3/4A serine protease, thereby blocking the cleavage of HCV polyprotein precursors essential for viral replication. Inhibiting this proteolysis disrupts the assembly of the HCV replication complex, resulting in marked suppression of intracellular HCV RNA synthesis and replication across various HCV genotypes. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(130.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Paritaprevir (ABT-450) Clinical Trials
- Paritaprevir (ABT-450) Solubility in DMSO
- Paritaprevir (ABT-450) Stock Solution
- Paritaprevir (ABT-450) Storage
- Paritaprevir (ABT-450) Stability
- Paritaprevir (ABT-450) Molecular Weight
- Paritaprevir (ABT-450) SMILES
- Paritaprevir (ABT-450) Chemical Structure (2D and 3D)
- Paritaprevir (ABT-450) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.