CAS No. 198470-85-8
Batch:
Purity:99.97
Chemical Structure
Check the
Parecoxib Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium [4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide | |
|---|---|---|
| CAS Number | 198470-85-8 | |
| Molecular Formula |
C19H17N2NaO4S |
|
| Molecular Weight (MW) | 392.4 | |
| SMILES | CCC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C.[Na+] | |
| InChIKey | HQPVVKXJNZEAFW-UHFFFAOYSA-M |
Parecoxib Sodium is a water-soluble prodrug of valdecoxib that acts as a potent and selective cyclooxygenase-2 (COX-2) inhibitor. Upon enzymatic conversion to valdecoxib, it suppresses COX-2-mediated synthesis of prostaglandin E2 (PGE2) without significantly inhibiting COX-1. This targeted inhibition disrupts inflammatory signaling pathways, leading to reduced tissue inflammation and potent analgesic phenotypes in preclinical models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 12.5 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.