CAS No. 269718-83-4

Batch: Purity:99.77
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Pardoprunox (SLV-308) hydrochloride Chemical Structure
Chemical Structure
Check the Pardoprunox (SLV-308) hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 269718-83-4
Molecular Formula

C12H16ClN3O2
Molecular Weight (MW) 269.73
SMILES CN1CCN(CC1)C2=CC=CC3=C2OC(=O)N3.Cl

Ordering Information

Biological Activity

Pardoprunox hydrochloride is a partial agonist of dopamine D2 receptors (pEC50 = 8.0) and an agonist of serotonin 5-HT1A receptors (pEC50 = 6.3). By selectively targeting dopaminergic and serotonergic signaling pathways, the compound modulates G protein-coupled receptor activation and downstream effector cascades. These molecular interactions regulate synaptic transmission and central nervous system signaling, leading to significant downstream effects on motor function, movement control, and neurobehavioral phenotypes.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (111.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.