CAS No. 14255-87-9
Batch:
Purity:99.68
Chemical Structure
Check the
Parbendazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl N-(6-butyl-1H-benzimidazol-2-yl)carbamate | |
|---|---|---|
| CAS Number | 14255-87-9 | |
| Molecular Formula |
C13H17N3O2 |
|
| Molecular Weight (MW) | 247.29 | |
| SMILES | CCCCC1=CC2=C(C=C1)N=C(N2)NC(=O)OC | |
| InChIKey | YRWLZFXJFBZBEY-UHFFFAOYSA-N |
Parbendazole is a potent benzimidazole-class inhibitor of microtubule assembly that selectively targets tubulin. By binding to tubulin subunits, the compound effectively disrupts microtubule polymerization dynamics and destabilizes the mitotic spindle architecture. This inhibition impairs essential intracellular transport pathways, halts cell cycle progression at the G2/M phase, and induces apoptotic cell death, leading to the suppression of cellular proliferation.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(12.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.