CAS No. 352017-71-1

Batch: Purity:99.78
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PAR-4 Agonist Peptide, amide Chemical Structure
Chemical Structure
Check the PAR-4 Agonist Peptide, amide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 352017-71-1
Molecular Formula

C34H48N8O7
Molecular Weight (MW) 680.80

Ordering Information

Biological Activity

PAR-4 Agonist Peptide, amide is a selective synthetic agonist targeting proteinase-activated receptor-4 (PAR-4). Upon binding, it stimulates PAR-4 receptors localized on peripheral sensory neurons and colonic nerve terminals, thereby modulating downstream nociceptive signaling pathways. This receptor activation produces pronounced antinociceptive effects, resulting in the attenuation of visceral hypersensitivity and the suppression of stress- and inflammation-induced hyperalgesia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (146.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 25 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.