CAS No. 248282-01-1

Batch: Purity:99.95
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Paquinimod (ABR-215757) Chemical Structure
Chemical Structure
Check the Paquinimod (ABR-215757) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
CAS Number 248282-01-1
Molecular Formula

C21H22N2O3
Molecular Weight (MW) 350.41
SMILES CCN(C(=O)C1=C(O)C2=C(CC)C=CC=C2N(C)C1=O)C3=CC=CC=C3
InChIKey DIKSYHCCYVYKRO-UHFFFAOYSA-N

Biological Activity

Paquinimod (ABR-215757) is a small-molecule immunomodulator that acts as a specific inhibitor of the S100A8/A9 protein complex. By disrupting S100A8/A9 interactions with downstream pro-inflammatory receptors, paquinimod suppresses signal transduction pathways and prevents pathogenic neutrophil activation. In viral pneumonia models, paquinimod rescues lung pathology, mitigates tissue damage, and substantially reduces viral loads in SARS-CoV-2 infection.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 70 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 17 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.