CAS No. 870653-45-5
Batch:
Purity:99.84
Chemical Structure
Check the
PAP-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 870653-45-5 | |
|---|---|---|
| Molecular Formula |
C21H18O5 |
|
| Molecular Weight (MW) | 350.37 | |
| SMILES | O=C1OC2=CC3=C(C=CO3)C(=C2C=C1)OCCCCOC4=CC=CC=C4 |
PAP-1 is a potent and selective blocker of the voltage-gated potassium channel Kv1.3 (EC50 2 nM). By blocking Kv1.3 channel activity, PAP-1 impairs calcium signaling and inhibits the proliferation and functional activation of human effector memory T cells. Consequently, treatment with PAP-1 suppresses downstream inflammatory cytokine production and effectively reduces delayed-type hypersensitivity responses in vivo. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.